The influence of reflux on esophageal glutathione levels was also examined. Sprague dawley rat taconic biosciences pdf book manual. Palm puree is rich in antioxidants and is produced via blending various proportions of mesocarp fibre and crude palm oil. It is the most widely used rat model for biomedical research. To address how rvfv infection during pregnancy causes detrimental effects on the fetus, we developed a pregnant rodent model of rvfv infection. Spraguedawley rat article about spraguedawley rat by. Mixed reflux caused more gross mucosal injury than acid reflux. The rat is the most commonly used rodent species for toxicology studies. The second was a threegeneration dietary assay conducted over the dose range 1.
You can manage this and all other alerts in my account. Pdf genetic background in animal models is an intrinsic research. The administration of agnps to rats significantly enhanced the ros level at four tested doses as compared to the control animals. Metabolic differences between sprague dawley and wistar. Esophagitis in spraguedawley rats is mediated by free. Fourweekold male and female, specificpathogen free spf sprague dawley rats were purchased from orient bio korea and acclimated for 7 days before starting the experiments. The list of acronyms and abbreviations related to sds spraguedawley rats. Splenic hemangiosarcoma in a young spraguedawley rat. During the acclimation and experimental periods, the rats were housed in polycarbonate cages maximum of 3 rats per cage in a room with controlled temperature.
Spraguedawley and wistar rats are both established models of. The 90day toxicology feeding experiment was conducted in spraguedawley rats fed with diets containing 70% of either trs rice flour, its nearisogenic rice flour or the control diet. Lewis, fischer 344, and spraguedawley rats display. Spraguedawley rats rattus norvegicus specific pathogen free for. Outbred sprague dawley rats are among the most commonly used rats for neuroscience. The rats average about 5 grams of food per day per 100 grams of body weight and about 1012 milliliters of water per 100 grams of body weight. The objective of this study was to evaluate the toxic characteristics of rauvolfia tetraphylla leaf extract in sprague dawley rats after treatment for minimum 7 days by oral route. Spraguedawley and wistar rats are both established models of sucroseinduced ir and hypertg pagliassotti et al. Comparative analysis of growth characteristics of sprague dawley.
We will breed up to 3 founders to wildtype rats of matching strain background and genotype their offspring to obtain f1 rats bearing the transgene. Ijerph free fulltext the accumulation and metabolism. The study was conducted according to oecd guideline 407. Studies on the antidiabetic activities of cordyceps. The first was a twogeneration assay conducted using the oral route over the dose range 0. Sprague dawley rat synonyms, sprague dawley rat pronunciation, sprague dawley rat translation, english dictionary definition of sprague dawley rat. Figure 4 summarizes the detection of intracellular production of ros in spraguedawley rats exposed to agnps and controls. Reference values for young normal spraguedawley rats. The rats were housed in individually ventilated temperature and humidity controlled cages strain and agematched two per cage with hardwood chip bedding. Healthy rats will live from two and a half to three years depending on the strain, sex, environmental conditions, and other variables baker, lindsey and weisbroth, 1980. Male spraguedawley rats 90120g body weight bred and maintained at the biomedical research unit, university of kwazulunatal was used in this study. All books are in clear copy here, and all files are secure so dont worry about it. Reproductive and teratogenic effects of lidocaine in. The aim of this study was to assess the acute and subchronic toxicity of palm puree in male and female sprague dawley rats.
This study shows that physicochemical and sensory attributes of pasteurized buffalo milk fortified with ferrous sulfate 0. However, you may choose to have us breed the founders further to obtain f1 rats. Background hematologic and biochemical analytes of spraguedawley rats are commonly used to determine effects that were induced by treatment and to evaluate organ dysfunction in toxicological safety assessments, but reference intervals have not been well established for these analytes. A number of rat species are used in research, contract research organizations and in the pharmaceutical industry including the wistar, sprague dawley and fischer 344. Like other rat breeds used in research, the sprague dawley makes for a good general model for the study of human toxicology, reproduction, pharmacology, and behavioral research.
The experimental procedure was approved by the laboratory animal center at army medical university, chongqing. Free radicalmediated esophagitis was studied during duodenogastroesophageal reflux mixed reflux or acid reflux in rats. Sprague dawley rats were slightly, more sensitive than the wistar strain for effects on bp and nephron endowment. The sprague dawley outbred model was developed by sprague dawley, inc. Sprague dawley sd rat has a wide array of historical research use including in the field of cardiology.
Spontaneous neoplastic lesions in aged spraguedawley rats. The common domestic rat, which is found worldwide and is a destructive pest of crops and stored food and a carrier of disease. History of the sprague dawley rat erikacarlys weblog. Reference intervals as presently defined for these analytes in spraguedawley rats. For the acute toxicity study, animals administered single palmpuree doses 2000 mg kg. This study evaluates the oestrogenic activities of aqueous root extract and screens for possible bioactive phytochemicals. Pdf comparative analysis of growth characteristics of sprague. Animals from low, mid and high dose groups received leaf extract at 250, 500 and mgkgday, respectively. Reproductive and teratogenic effects of lidocaine in spraguedawley rats you will receive an email whenever this article is corrected, updated, or cited in the literature. Taconic offers the sprague dawley outbred rat at the standard murine pathogen free health status which is appropriate for most studies. Dawley from a hybrid hooded male and a female wistar rat. Charles river provides laboratory animal models, including the sprague dawley rat, for use in basic research and nonclinical drug discovery and. Fat intake affects adiposity, comorbidity factors, and. Established in 1925 by robert dawley, the original sprague dawley rat colony was obtained by harlan in 1980 through the acquisition of spraguedawley, inc.
It can be concluded that pasteurized milk can be an effective vehicle to fortify iron in combination with vitamin c. Spontaneous tumors in spraguedawley rats and swiss mice1. Sprague dawley rats were first bred by the sprague dawley farm in madison, wisconsin in 1925 through multiple crosses with a singlehooded male and six albino female rats. About sprague dawley rats lauren and heathers blog. Altered health outcomes in adult offspring of sprague. Pdf download for reference values for young normal spraguedawley rats. The incidence and increased severity of the disease occurs more frequently in the aging male rat than in female rats, and in certain lab species namely f344 and spraguedawley rats and to a much lesser degree in wister and long evans hooded rats. Spraguedawley rat definition of spraguedawley rat by.
The sprague dawley breed of rat, like those used in the current psychology 381 class, is used widely throughout medical and psychological research. Established in 1925 by robert dawley, the original sprague dawley rat colony was obtained by harlan in 1980 through the acquisition of sprague dawley, inc. Pdf acute oral toxicity effects of momordica charantia. Spraguedawley rat synonyms, spraguedawley rat pronunciation, spraguedawley rat translation, english dictionary definition of spraguedawley rat. Defined flora spraguedawley rodents are relatively shortlived at approximately 2 years. Nih received stock from sprague dawley, inc in 1945.
This site is like a library, you could find million book here by using search box in the header. Mccomb dj, kovacs k, beri j, zak f 1984 pituitary adenoma in old spraguedawley rats. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle to ovalshaped cells that showed invasive growth without encapsulation and were. Sprague dawley rat synonyms, sprague dawley rat antonyms. Sprague dawley rat definition of sprague dawley rat by. Tumors in spraguedawley rats and swiss mice table 2 location of 219 spontaneous tumors occurring in 165 60 males and 105 females of 360 spraguedawley rats observed for 540 days site and tumor male female skin and s.
Effect on sperm production in adult spraguedawley rats. Rift valley fever virus rvfv infections in pregnant livestock cause high rates of fetal demise. Inhibition of testosteroneinduced hyperplasia of the. I am a model organism used by duke university to research the impacts of chemical exposure on behavior, memory, and cognitive ability. The animals had free access to standard rat chow meadows feeds, pietermaritzburg, south africa and water, with a 12hour light12hhour dark cycle. Biopersistence of silver nanoparticles in tissues from. Cdsdbr that were on randomly selected toxicity studies at the huntingdon research centre between 1981 and 1984 at time points of 8, 17, 30, 56, and 108 weeks. Agerelated changes in thyroid structure and function in. Taconic received stock from the nih animal genetic resource in 1970. The sd rats from charles river laboratories crl and harlan.
Sprague dawley rats obtained from different sources. Read online sprague dawley rat taconic biosciences book pdf free download link book now. The present report describes a rare case of spontaneous hemangiosarcoma in a nineweekold male spraguedawley rat. Request pdf metabolic differences between sprague dawley and wistar han male rats while sprague dawley sd rats are often used for nonclinical safety testing, wistar han wh rats are also. The weights of the rats were recorded weekly, and the influence of testosterone and pumpkin seed. Streptobacillus moniliformis, streptococcus f3 haemolitica, bordetella. They had free access to altrominr pellet diet except in starvation experiments and to tap. To produce experimental model of diabetes, 42 male spraguedawley rats were administrated with a modified high fat high sucrose diet hfhsd. Evaluation of the chronic toxicity and carcinogenicity of. Genetic characterization of outbred sprague dawley rats. Almost all laboratory and domestic pet rats belong to a single species, the norway rat rattus norvegicus. Also, huff 2002 reported that the positive ri findings for toluene were less than overwhelming, the negative ntp findings for vinylidene chloride less than adequate because the use of a maximum tolerated dose mtd had not been clearly demonstrated, and the positive ri findings for vinylidene chloride were for increases in leukemias and total malignant tumors in sprague.
Sprague dawley rat article about sprague dawley rat by. Carcinogenicity studies in spraguedawley sd rats show that pfoa induces the tumor triad pattern liver adenomas, leydig cell tumors, and pancreatic acinar cell tumors similar to several peroxisome proliferatoractivated receptor alpha ppar. Sexspecific reference intervals of hematologic and. We selected 100 specific pathogen free spf female spraguedawley rats, 34 weeks old and weight 7090g, and all the animals were provided by the laboratory animal center of army medical university no. The rats were refreshed with nih genetic resource stock in 1998. The current study aims to investigate the influence of five rare earth elements rees i.
Materials and methods data for the morphologic studies were obtained from 500 male and 500 female control spraguedawley rats crl. Dawley rats were randomly divided into three groups n10, including the control, oa and oa with treadmill exercise oae groups. The rats are maintained as an outbred closed colony. Hypoglycemic activity of cucumis sativus extract on. Simultaneous oral administration of either pumpkin seed oil 2. Spraguedawley sd and long evans strains are available for transgenic rat production. Longterm health effects occured with undernutrition during either window examined in this study, but the uni021 period resulted in lower birth weight and more severe effects later in life. Evaluating the oestrogenic activities of aqueous root.
Illumina truseq pcrfree library prep kit and quality checked using an. Rift valley fever virus induces fetal demise in sprague. Sprague dawley rat an overview sciencedirect topics. In 1991, 8 colonies were selected to form the igs foundation colony.
981 221 446 440 1058 374 348 1417 1521 1250 1428 465 782 732 1086 517 1525 1182 1169 565 436 601 1179 1181 1140 810 1024 233 359 376 720 1234 1534 1195 1260 1102 1402 1206 200 1293 300 731 1012 245 303 382 204